Comparing the Advantages and Disadvantages of the Popular Anti-Diabetes Drugs

diabetic drugs
Use of antidiabetic drugs should comply with the treatment regimen of the doctor

Type 2 diabetes is when the body can still produce insulin, but it does not produce enough insulin or because the cells can not use insulin. Type 2 diabetics do not need insulin injections like type 1, but must resort to hypoglycemic agents. However, on the market today, there are countless drugs and patients often do not know all the side effects of the drug they are using. To better understand the advantages and disadvantages of each type 2 diabetes drug group, please refer to the article below.

1. Classes of Drugs commonly used in Diabetes treatment

Many people with type 2 diabetes maintain a steady blood sugar level through persistent exercise and a combination of a healthy diet. However, in other cases, drugs or insulin therapy are needed.

The decision on which drug to take will depend on many factors, the most important being the HbA1c (sugar binding index on red blood cells) and the patient’s current health status. Accordingly, some drugs used in the treatment of type 2 diabetes include the following groups:

  • The drug increases insulin sensitivity.
  • The drug causes increased insulin secretion.
  • The drug works to slow the absorption of fats and glucose from the intestine.
  • Insulin.

2. Advantages and Disadvantages of each group of Diabetes Drugs

2.1. The Drugs increases Insulin sensitivity

This group is divided into 4 sub-groups including:

Metformin drugs popular type 2
Metformin is a popular type 2 diabetes drug
  • Metformin (Biguanide) 
Metformin is a treatment for diabetes in Biguanid group which is being used very much today. That is why it is very important to understand and use this medicine correctly. 
Metformin is an oral medication that controls blood sugar and does not cause weight gain. One off drugs which is often prescribed for overweight and obese subjects, but its effectiveness is comparable to that of non-obese people. The drug works by reducing blood sugar by inhibiting glucose regeneration. Mechanically, metformin reduces the synthesis of glucose in the liver, and increases insulin sensitivity to fat and muscle cells.
Advantages: Inexpensive, does not cause hypoglycemia if used alone, does not change body weight, reduces the absorption of bad cholesterol and triglycerides, prevents cardiovascular risks.
Disadvantages: Not suitable for patients with renal impairment (especially those with GFR <30ml / min). The patient may experience some digestive symptoms such as anorexia, indigestion, diarrhea …
  • Thiazolidinedione (TZD)
Thiazolidinedione (or glitazone) is an effective group of drugs to reduce blood glucose in patients with type 2 diabetes. TDZ includes two common active ingredients, rosiglitazone and pioglitazone. Both play a role in increasing the body’s sensitivity to insulin, helping to control blood sugar levels.
Advantages: Similar to metformin and especially can be combined with other drugs to increase effectiveness.
Disadvantages: Causes swelling (edema) and sudden weight gain (common in women), impaired vision and increased risk of bladder cancer, heart failure.
  • GLP-1 receptor agonists

In addition to increasing insulin sensitivity, GLP-1 receptor agonists also work to increase insulin secretion, limit liver glucose neogenesis, and reduce appetite. The active ingredient commonly used in the group is exenatide.

Advantages: Can be used in obese patients with postprandial hyperglycemia, low risk of hypoglycemia, GLP-1 is indicated for use with metformin when this drug is no longer effective if used alone.

Disadvantages: Easy to cause abdominal pain, nausea when used, contraindicated for patients with kidney failure or a history of thyroid tumor or thyroid cancer. Acute pancreatitis should also be avoided although more research is needed to prove it. In addition, the drug must be used by injection.

  • Dipeptidyl peptidase-4 (DDP-4) diabetes drug

DPP-4 inhibitors group also known as gliptin, including active ingredients such as sitagliptin, vildagliptin, saxagliptin … This is considered a new class of drugs in the treatment of type 2 diabetes. The mechanism of action of the drugs increases insulin secretion and decreases glucagon formation in the liver.

Advantages: Less side effects, well tolerated does not cause hypoglycemia when used alone, can be used for people with chronic kidney disease, the elderly.

Disadvantages: Not as highly effective as GLP-1 receptor agonists, more expensive than metformin, which can cause allergies, itching, redness …

2.2. The Drugs causes increased Insulin secretion

These drugs stimulate the pancreas to secrete more insulin, which in turn helps to regulate blood sugar. Currently, there are two groups of insulin secretion stimulants: Sulfonyureas (Glimepiride, Glibenclamide, Gliclazide, Glipizide) and Glinides (Repaglinide, Nateglinide).

  • Sulfonyureas

These diabetes drugs play a role in stimulating the pancreas to secrete insulin. This hormone prevents the release of glucose from the liver and increases the synthesis of glycogen (the main storage form of glucose in the body).

Advantages: Low cost, most drugs in the group have been thoroughly researched, when used can reduce the risk of complications of small blood vessels and cardiovascular diseases.

Disadvantages: Continuous use of patients is likely to have hypoglycemia and mild weight gain.

  • Glinides

Although having a similar effect to the sulfonyureas group, this group of diabetes drugs is characterized by a rapid effect after use and a shorter duration of action. Therefore, doctors often recommend patients to take medication right before meals.

Advantages: Can be used for patients with kidney failure.

Disadvantages: Expensive and easy to cause hypoglycemia if not taken with meals.

2.3. The Drugs work to slow the absorption of Fats and Glucose from the intestine

Typically in this group of diabetes drugs are alpha – glucosidase inhibitors (Acarbose) and lipase enzyme inhibitors (orlistat).

  • Alpha-glucosidase inhibitors

The mechanism of action of this group of diabetes drugs inhibits the breakdown of carbohydrates into glucose in the small intestine, thereby preventing glucose from entering the bloodstream, reducing the sudden hyperglycemia after eating. A special feature of the enzyme alpha-glucosidase inhibitors is that it is not insulin related.

Advantages: There is no risk of hypoglycemia when used.

Disadvantages: bloating, bloating, constipation due to slow digestion, in addition high cost.

  • Lipase inhibitors

Lipase is an enzyme that breaks down the structure and helps fat to absorb through the intestines. Undigested fat will be eliminated from the body. This class of drugs is often used to aid weight loss in the treatment of type 2 diabetes. However, you should consult your doctor before taking it. The disadvantage of this group is that it can limit absorption of oil-soluble vitamins or cause diarrhea.

2.4. Insulin

In some cases, people with type 2 diabetes need insulin therapy because diet, exercise, and oral diabetes medications do not reach their target blood glucose levels.
Hypoglycemia insulin injection
Insulin injection is one of the major complications of diabetes when not controlling well blood sugar levels leads to excessive insulin use.
Advantages: For quick effect.
Disadvantages: Can cause excessive hypoglycemia if multiple types of insulin are used for treatment. High cost, need to know injection technique if you want to do it yourself.

A well-balanced and rational diet has a significant impact on the effectiveness of disease treatment. Because, any food you consume has the ability to change the blood glucose index. To limit this effect, you should pay more attention to calculating your carbohydrate intake, and you should split meals to avoid the risk of sudden hypoglycemia.

With snacks, you can choose to use diabetes milk. Thanks to scientific advances, a few types on the market today not only provide essential nutrients but also help patients to control the levels of insulin secreted. There are even types that add myo inositol, which is one of the nine isomers of inositol that play a role in increasing insulin sensitivity. This is essential for people with type 2 diabetes.

Another way your body uses insulin effectively is to actively exercise, control your weight and keep yourself from stress and pressure. With excercise, patients need to consult their doctor to choose safe and suitable exercises for their medical conditions. The good excercise of these measures can sometimes help the patient reduce the frequency of taking medications and keep blood sugar levels stable for a long time.

》》》 Learn more: 

Which Milk Should I Choose for People with Diabetes?  

Above are basic information about diabetes drug groups with the advantages and disadvantages of each. Hopefully, through this article, you can equip yourself with useful knowledge about using medicines to ensure good health.

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What snacks do not raise blood sugar and is good for diabetics?


Dear friend !

Diabetes is considered a chronic disease and many people have difficulty in treating it. Currently, if only for rapid rapid hypoglycemia within 5-7 days, patients can take western medicine, but this is extremely dangerous for your health. On the contrary, if you are looking for the key to the safest and most effective diabetes treatment that is good for your long-term health, then this article is exactly for you.

Most of us know how dangerous diabetes is?. If you have just diagnosed that you have diabetes or you have diabetes for a long time, this disease will follow you all your life, although you do not want to believe, the disease is still affecting your life. Because there is currently no cure for you completely, this disease can kill you or your loved one at any time?.

The untimely and improperly treated diabetes will cause many unpredictable consequences for your health. In it, the scariest thing about diabetes is what? Do you know ?. It is a situation in which “one disease develops another” over time in a vicious cycle that makes health more and more depleted, using more and more medicine and the frequency of going in and out of the hospital.

Therefore, The best current natural remedies for type 2 diabetes are to change to low carb diet, high fiber, low sugar fruits and exercise regularly to control blood sugar. If you don’t know how to start, you can refer Rachel Roberts’ 8-week Keto diet, which helps you with weight loss and blood sugar control. I think this program is very specific and detailed and effective. Let’s start today to take control of this so-called “Silent Killer” disease.

Custom Keto Diet plan for your weight loss

custom keto
Custom Keto Diet plan for your weight loss


》》》 Learn more:

Custom Keto Diet- The Most Effective Weight Loss Solution in 8-Week





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